U.S. scientists have reconstructed the 1918 virus (A/South Carolina/1/1918) from gene sequences (Science, 7 October issue). This virus, unlike modern human flu strains and like the "bird flu" strains, is highly pathogenic in mice and chicken eggs. Using mix-and-match techniques, they also show that the genes that are required for the exceptional virulence of this virus encode the viral glycoprotein HA and the viral polymerase subunit PB2. Why?? We are trying to get our hands on the 1918 HA gene to do some experiments...
-Kartik
PS: Bird flu in Turkey, Romania, and maybe, Greece and Croatia. Transmission is thought to be through infected migratory birds. If these guys reach Africa, we're in deep s***. For regular updates, sign up at www.promedmail.org.
-k
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